Immunosuppressive regimen renal transplant
Common Immunosuppressive Regimens: Risks, Benefits and Appropriate Use Stuart M. Flechner, MD, FACS Professor of Surgery, Glickman Urological and Kidney Institute Transplant Center Cleveland Clinic Lerner College of MedicineKidney transplantation today has excellent shortterm outcomes, but longterm graft survival has not improved in a parallel fashion. The goal of immunosuppressive therapy is to balance the beneficial effects of reducing acute rejection while minimizing adverse effects from oversuppression including the development of infections, malignancy, and cardiovascular risk factors. immunosuppressive regimen renal transplant
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GoldfarbRumyantzev AS, Smith L, Shihab FS, et al. Role of maintenance immunosuppressive regimen in kidney transplant outcome. Clin J Am Soc Nephrol 2006; 1: 563. Remuzzi G, Lesti M, Gotti E, et al. Mycophenolate mofetil versus azathioprine for prevention of acute rejection in renal transplantation (MYSS): a randomised trial. Sirolimus (SRL)based immunosuppressive regimens have been used for preventing rejection after kidney transplantation. This review analyzes their merits and demerits compared with other conventional regimes from the aspects of acute rejection rate,immunosuppressive regimen renal transplant The initial transplant armamentarium consisted only of azathioprine and steroids for maintenance immunosuppression in renal transplantation until the 1980s, when the first calcineurin inhibitor, cyclosporine became available.